Celiprol

Celiprol may be available in the countries listed below.

Ingredient matches for Celiprol

Celiprolol

Celiprolol is reported as an ingredient of Celiprol in the following countries:

• Tunisia

International Drug Name Search

Topiramat-CT

Topiramat-CT may be available in the countries listed below.

Ingredient matches for Topiramat-CT

Topiramate

Topiramate is reported as an ingredient of Topiramat-CT in the following countries:

• Germany

International Drug Name Search

Benzoylperoxid Riemser

Benzoylperoxid Riemser may be available in the countries listed below.

Ingredient matches for Benzoylperoxid Riemser

Benzoyl Peroxide

Benzoyl Peroxide is reported as an ingredient of Benzoylperoxid Riemser in the following countries:

• Germany

International Drug Name Search

Noprilex

Noprilex may be available in the countries listed below.

Ingredient matches for Noprilex

Paroxetine

Paroxetine hydrochloride (a derivative of Paroxetine) is reported as an ingredient of Noprilex in the following countries:

• Greece

International Drug Name Search

Hydromorphone

In the US, Hydromorphone (hydromorphone systemic) is a member of the drug class narcotic analgesics and is used to treat Anesthetic Adjunct, Cough and Pain.

US matches:

• Hydromorphone


• Hydromorphone Extended-Release


• Hydromorphone Extended-Release Capsules


• Hydromorphone High-Potency


• Hydromorphone Liquid


• Hydromorphone Suppository


• Hydromorphone Tablets


• Hydromorphone injection


• Hydromorphone rectal


• Hydromorphone Hydrochloride


• Hydromorphone tablets, solution

Scheme

Rec.INN

ATC (Anatomical Therapeutic Chemical Classification)

N02AA03

CAS registry number (Chemical Abstracts Service)

0000466-99-9

Chemical Formula

C17-H19-N-O3

Molecular Weight

285

Therapeutic Category

Opioid analgesic

Chemical Name

Morphinan-6-one, 4,5-epoxy-3-hydroxy-17-methyl-, (5α)-

Foreign Names

• Hydromorphonum (Latin)
• Hydromorphon (German)
• Hydromorphone (French)
• Hidromorfona (Spanish)

Generic Names

• Hydromorphone (OS: BAN, DCF)
• Idromorfone (OS: DCIT)
• Dihydromorphinone (IS: WHO)
• Laudacon (IS)
• Hydromorphone (PH: NF XIV)
• Hydromorphone Hydrochloride (OS: BANM)
• Cormophin (IS)
• Dihydromorphinone Hydrochloride (IS: WHO)
• Laudadin (IS)
• Laudamed (IS)
• Percoral (IS)
• Procorman (IS)
• Scolaudol (IS)
• Hydromorphone hydrochloride (PH: Ph. Eur. 6, USP 32)
• Hydromorphone Hydrochloride (PH: BP 2010)
• Hydromorphoni hydrochloridum (PH: Ph. Int. 2, Ph. Eur. 6)

Brand Names

• Dilaudid
  Mundipharma, Australia; Purdue Pharma, Canada; Purdue Pharma, United States



• Dilaudid-HP
  Abbott, United States



• Dolonovag
  Gobbi, Argentina



• Hydal retard
  Mundipharma, Austria



• Hydal
  Mundipharma, Austria



• Hydromorph Contin
  Purdue Pharma, Canada



• Hydromorphon-AL
  Aliud, Germany



• Hydromorphon-AWD
  AWD.pharma, Germany



• Hydromorphon-dura
  Mylan dura, Germany



• Hydromorphone HCl
  Hospira, United States; Sandoz, Canada; Teva USA, United States; Wyeth, United States



• Hydromorphone Hydrochloride Injection
  Mayne, United States



• Hydromorphone Hydrochloride
  Actavis, United States; Baxter, United States; Endo, United States; Ethex, United States; Hospira, United States; KV Pharmaceutical, United States; Lannett, United States; Mallinckrodt, United States; Mayne, United States; Paddock, United States; Roxane, United States; Tyco, United States; Vintage, United States



• Hydromorphone-Hexal
  Hexal, Germany



• Hydromorphone-ratiopharm
  Ratiopharm, Germany



• Hydromorphoni hydrochloridum Streuli
  Streuli Pharma, Switzerland



• Hydromorphon-Stada
  Hexal, Germany



• Hydromorphon-Winthrop
  Winthrop, Germany



• Jurnista
  Janssen, Australia; Janssen, Czech Republic; Janssen, Germany; Janssen, Spain; Janssen, Hungary; Janssen, Italy; Janssen-Cilag, Austria; Janssen-Cilag, Switzerland; Janssen-Cilag, Denmark; Janssen-Cilag, Lithuania; Johnson & Johnson, Estonia; Johnson & Johnson, Croatia (Hrvatska); Johnson & Johnson, Latvia; Johnson & Johnson, Slovenia; Johnson & Johnson, Slovakia



• Liberaxim
  Pisa, Mexico



• Palladon
  Mundipharma, Switzerland; Mundipharma, Germany; Mundipharma, Finland; Mundipharma, Netherlands; Mundipharma, Norway; Mundipharma, Sweden; Norpharma, Denmark; Norpharma, Iceland



• Palladon Comp (Hydromorphone and Atropine)
  Mundipharma, Sweden



• Palladone
  ExtractumPharma, Hungary; Medis, Slovenia; Medis Adria, Croatia (Hrvatska); Mundipharma, Belgium; Mundipharma, Czech Republic; Mundipharma, Estonia; Mundipharma, Hungary; Mundipharma, Ireland; Mundipharma, Lithuania; Mundipharma, Luxembourg; Mundipharma, Slovakia; Napp, United Kingdom; Rafa, Israel



• PMS-Hydromorphone
  Pharmascience, Canada



• Sophidone
  Bristol-Myers Squibb, France

International Drug Name Search

Glossary

BAN	British Approved Name
BANM	British Approved Name (Modified)
DCF	Dénomination Commune Française
DCIT	Denominazione Comune Italiana
IS	Inofficial Synonym
OS	Official Synonym
PH	Pharmacopoeia Name
Rec.INN	Recommended International Nonproprietary Name (World Health Organization)
WHO	World Health Organization

Click for further information on drug naming conventions and International Nonproprietary Names.

Tritazide

Tritazide may be available in the countries listed below.

Ingredient matches for Tritazide

Hydrochlorothiazide

Hydrochlorothiazide is reported as an ingredient of Tritazide in the following countries:

• Austria


• Belgium


• Croatia (Hrvatska)


• Netherlands


• Slovakia


• Slovenia


• Tunisia

Ramipril

Ramipril is reported as an ingredient of Tritazide in the following countries:

• Austria


• Belgium


• Croatia (Hrvatska)


• Netherlands


• Slovakia


• Slovenia


• Tunisia

International Drug Name Search

Azitromycine Actavis

Azitromycine Actavis may be available in the countries listed below.

Ingredient matches for Azitromycine Actavis

Azithromycin

Azithromycin is reported as an ingredient of Azitromycine Actavis in the following countries:

• Netherlands

International Drug Name Search

Aceterin

Aceterin may be available in the countries listed below.

Ingredient matches for Aceterin

Cetirizine

Cetirizine dihydrochloride (a derivative of Cetirizine) is reported as an ingredient of Aceterin in the following countries:

• Estonia


• Latvia


• Lithuania

International Drug Name Search

Worming Cream

Worming Cream may be available in the countries listed below.

In some countries, this medicine may only be approved for veterinary use.

Ingredient matches for Worming Cream

Piperazine

Piperazine citrate (a derivative of Piperazine) is reported as an ingredient of Worming Cream in the following countries:

• United Kingdom

International Drug Name Search

Tramadol STADA

Tramadol STADA may be available in the countries listed below.

Ingredient matches for Tramadol STADA

Tramadol

Tramadol hydrochloride (a derivative of Tramadol) is reported as an ingredient of Tramadol STADA in the following countries:

• Bosnia & Herzegowina


• Bulgaria


• Germany


• Russian Federation


• Singapore


• Spain


• Sweden


• Taiwan


• Vietnam

International Drug Name Search

Medimacrol

Medimacrol may be available in the countries listed below.

Ingredient matches for Medimacrol

Azithromycin

Azithromycin dihydrate (a derivative of Azithromycin) is reported as an ingredient of Medimacrol in the following countries:

• Guatemala

International Drug Name Search

Alka-Selzer

Alka-Selzer may be available in the countries listed below.

Ingredient matches for Alka-Selzer

Aspirin

Acetylsalicylic Acid is reported as an ingredient of Alka-Selzer in the following countries:

• Canada

Sodium Bicarbonate

Sodium Bicarbonate is reported as an ingredient of Alka-Selzer in the following countries:

• Canada

International Drug Name Search

Ranitin

Ranitin may be available in the countries listed below.

Ingredient matches for Ranitin

Ranitidine

Ranitidine is reported as an ingredient of Ranitin in the following countries:

• Ethiopia

Ranitidine hydrochloride (a derivative of Ranitidine) is reported as an ingredient of Ranitin in the following countries:

• India


• Lithuania


• Poland

International Drug Name Search

Glycerol

In some countries, this medicine may only be approved for veterinary use.

In the US, Glycerol is a member of the drug class laxatives and is used to treat Constipation and Cough.

Scheme

Rec.INN

ATC (Anatomical Therapeutic Chemical Classification)

A06AG04,A06AX01

CAS registry number (Chemical Abstracts Service)

0000056-81-5

Chemical Formula

C3-H8-O3

Molecular Weight

92

Therapeutic Categories

Laxative, Enema

Laxative, lubricant

Laxative, osmotically acting

Chemical Name

1,2,3-Propanetriol

Foreign Names

• Glycerolum (Latin)
• Glycerol (German)
• Glycérol (French)
• Glicerol (Spanish)

Generic Names

• Glycerin (OS: JAN)
• Glycérol (OS: DCF)
• E 422 (IS)
• Glycerin (PH: USP 32, JP XV)
• Glycerol (PH: BP 2010, Ph. Int. 4, Ph. Eur. 6)
• Glycérol (PH: Ph. Eur. 6)
• Glycerolum (PH: Ph. Int. 4, Ph. Eur. 6)

Brand Names

• Adulax
  Casen, Spain



• Adult Glycerol
  Martindale, Oman



• ALK Soluprick Negativ kontrol
  ALK Abelló, Denmark



• Babylax
  Mann, Luxembourg; Zuoz, Venezuela



• Barra
  Neutrogena, Argentina



• Bébégel
  Meda, Malta; Meda, Portugal; Meda, France



• Bulboid
  Melisana, Switzerland



• Calas de Glycerina Cifsa
  Cifsa, Ecuador



• Cardiplast
  Optipharm, Greece



• Colace
  Shire, United States



• Comosup
  Farmasierra, Spain



• Cristal Adultes
  Cooper, France



• Cristal Enfants (pediatric)
  Cooper, France



• Cristal Nourrissons (pediatric)
  Cooper, France



• Czopki Glicerynowe
  Aflopa, Poland; Cefarm Olsztyn, Poland; Farmjug, Poland



• Dagragel
  Meda, Portugal



• Dulcoenema
  Boehringer Ingelheim, Spain



• Egoderm Cream (Glycerol and Ichthammol)
  Ego, New Zealand



• Epi Soothe (veterinary use)
  Virbac, South Africa



• Farmino
  Bajer, Argentina



• Fenolo Marco Nova Argentia (Glycerol and Phenol)
  Nova Argentia, Italy



• Fenolo Marco Viti (Glycerol and Phenol)
  Marco Viti, Italy



• Fenolo Zeta (Glycerol and Phenol)
  Zeta, Italy



• Fleet Babylax
  CB Fleet, Malaysia; Dany, Peru; Fleet, Ecuador; Fleet, United States; Rider, Chile



• Fleet Glycerin Suppositories
  Baxter, New Zealand; Fleet, United States



• Fleet Supositorios de Glicerina
  Fleet, Ecuador



• Gely Lanzas
  Faes, Spain



• Gliceramin
  Behrens, Venezuela; Suiphar, Dominican Republic



• Glicerina Bidestil Cuve
  Perez Gimenez, Spain



• Glicerina Quimpe
  Quimpe, Spain



• Glicerina San Pellegrino
  Sanofi-Aventis, Italy



• Glicerina Supositorios
  Pfizer, Venezuela



• Glicerina
  Calidad, Venezuela; Medicalex, Colombia; OFA, Venezuela; Pasteur, Chile; Quilab, Peru



• Glicerinum
  Halychpharm, Georgia



• Glicerol Isdin
  Isdin, Spain



• Glicerol Narval Pharma
  Narval, Spain



• Glicerol Vilardell
  Vilardell, Spain



• Glicerolo + Sodio Cloruro Bioindustria Lim
  Bioindustria Lim, Italy



• Glicerolo + Sodio Cloruro Diaco
  Diaco, Italy



• Glicerolo + Sodio Cloruro Eurospital
  Eurospital, Italy



• Glicerolo + Sodio Cloruro Fresenius
  Fresenius, Italy



• Glicerolo + Sodio Cloruro Galenica
  Galenica Senese, Italy



• Glicerolo + Sodio Cloruro Monico
  Monico, Italy



• Glicerolo + Sodio Cloruro NovaSelect
  NovaSelect, Italy



• Glicerolo + Sodio Cloruro Panpharma
  Panpharma, Italy



• Glicerolo + Sodio Cloruro Salf
  Salf, Italy



• Glicerolo Afom
  AFOM, Italy



• Glicerolo Angelini
  Angelini, Italy



• Glicerolo Carlo Erba
  Carlo Erba, Italy



• Glicerolo Dynacren
  Dynacren, Italy



• Glicerolo Farmacologico
  Farmacologico, Italy



• Glicerolo Farve
  Farve, Italy



• Glicerolo Marco Viti
  Marco Viti, Italy



• Glicerolo New.Fa.Dem
  New.Fa.dem., Italy



• Glicerolo Nova Argentia
  Nova Argentia, Italy



• Glicerolo Pharma 30
  Pharma 30, Italy



• Glicerolo Pietrasanta
  Pietrasanta, Italy



• Glicerolo QualiFarma
  QualiFarma, Italy



• Glicerolo Ramini
  Ramini, Italy



• Glicerolo Sella
  Sella, Italy



• Glicerolo Sofar
  Sofar, Italy



• Glicerolo Zeta
  Zeta, Italy



• Glicerolo
  Mediplants, Greece



• Glicerolo Montefarmaco
  Montefarmaco OTC, Italy



• Glicerolo Zeta
  Zeta, Italy



• Glicerotens
  Llorens, Spain



• Gliserin-Kansuk-B
  Kansuk, Turkey



• Gliserin-Kansuk-K
  Kansuk, Turkey



• Glycan Udder (Glycerol and Sorbitol (veterinary use))
  DeLaval, Australia



• Glycenon (Glycerol and Fructose)
  I'rom SeiyakuAiromu, Japan



• Glyceol (Glycerol and Fructose)
  Chugai, Japan



• Glycereb (Glycerol and Fructose)
  Terumo, Japan



• Glycerin and Potash Solution (Glycerol and Potassium Hydroxide)
  Fudjimi Seiyakushiyo, Japan



• Glycerin Bebe Ni-The (pediatric)
  Ni-The, Greece



• Glycerin Suppositories
  Rekah, Israel; Thornton & Ross, Georgia



• Glycerin
  ACPC - Arab Center for Pharmaceutical and Chemical, Oman; LCM, Malta



• Glycerine Pfizer
  Pfizer, Singapore



• Glycerine Suppo's
  Kela, Belgium



• Glycerine Suppo's Enfant et Bébé (pediatric)
  Kela, Belgium



• Glycerine
  Carlo Erba, Ethiopia; Pfizer, Hong Kong; Rekah, Israel; Sam-On, Israel



• Glycerin-Suppositorien Fonte
  Fonte SA, Switzerland



• Glycerinzäpfchen Sanova
  Sanova, Austria



• Glycerol Oba
  OBA, Denmark



• Glycerol PSM
  PSM, New Zealand



• Glycerol Suppositories BP
  MaCarthys, Malta; Petrus, Australia



• Glycerol
  ABM, New Zealand; Chugai, Japan; MidWest, New Zealand; Multichem, New Zealand; PSM, New Zealand; Sedico, Bahrain; Sella, Malta



• Glycilax
  Engelhard, United Arab Emirates; Engelhard, Bahrain; Engelhard, Cyprus; Engelhard, Germany; Engelhard, Kuwait; Engelhard, Lebanon; Engelhard, Qatar



• Glycilax für Kinder (pediatric)
  Engelhard, Germany



• Glyerin Ni-The
  Ni-The, Greece



• Glykanchor
  Meiji Seika Kaisha, Japan



• Glymacken (Glycerol and Fructose)
  Mylan Pharmaceutical, Japan



• Glyoktyl (Glycerol and Docusate Sodium)
  Medic, Denmark



• Glypose (Glycerol and Fructose)
  Fuso Pharmaceutical, Japan



• Glyss
  Opalia, Tunisia



• Glyzerinzäpfchen Rösch
  Rösch & Handel, Austria



• Grenol (Glycerol and Fructose)
  Ajinomoto, Japan



• Gycerin F (Glycerol and Fructose)
  Hikari Seiyaku, Japan



• Hisiceol (Glycerol and Fructose)
  Nipro PharmaNipurofama, Japan



• Hunny
  Eskayef, Bangladesh



• Idedex (Glycerol and Povidone-Iodine (veterinary use))
  AgVantage Animal Health Products, Australia



• Infant Glycerol
  Martindale, Oman



• JD
  Jeidorufu Seiyaku, Japan



• Karicare Baby Ointment (Glycerol and Zinc oxide)
  Nutricia, New Zealand



• Karicare Breast & Body Cream
  Nutricia, New Zealand



• Kenei
  G Kenei Sakai SeiyakuTakeshi Sakai Seiyaku, Japan



• Laxavit (Glycerol and Docusate Sodium)
  Kela, Belgium



• Laxolyne
  Julphar, Bahrain; Julphar, Oman; Julphar, Tunisia



• Lempsin Dry Cough
  Reckitt Benckiser, New Zealand



• Lemsip Dry Cough
  Reckitt Benckiser, New Zealand



• Microcel
  CPH, Portugal



• Milax
  Berlin-Chemie, Germany



• Minica
  Sato Seiyaku, Japan



• Miniderm
  Aco Hud, Finland; Aco Hud, Norway; Aco Hud, Sweden



• Minitran
  Meda, Norway



• Nene-Lax
  Dentinox, Germany



• Nene-Lax (pediatric)
  Dentinox, Germany



• Neutrobar
  Darier, Mexico



• Nitropelet
  Zentiva, Czech Republic



• Norgalax (Glycerol and Docusate Sodium)
  Norgine, Germany; Norgine, Netherlands



• Oriental
  Oriental PharmaceuticalOrientaru Yakuhin, Japan



• Otodolor
  Ursapharm, Germany



• Paidolax
  Casen, Spain



• Practomil
  B. Braun Medical, Switzerland



• Prolax
  Jadran, Croatia (Hrvatska)



• Q.V. Bar
  Ego, Australia



• QV Wash
  Ego, Hong Kong; Ego, New Zealand; Ego, Singapore



• Rectiofar
  Pharmedic, Vietnam



• Sani-Supp
  G & W, United States



• Spray & Dip RTU (Glycerol and Povidone-Iodine (veterinary use))
  DeLaval, Australia



• Supogliz
  Perez Gimenez, Spain



• Supositorio de Glicerina
  Oysa, Peru; UQP, Peru; Volta, Chile



• Supositorios de Glicerina Cuve
  Perez Gimenez, Spain



• Supositorios de Glicerina Fecofar
  Fecofar, Argentina



• Supositorios de Glicerina Franklin
  Millet, Argentina



• Supositorios de Glicerina
  Basi, Portugal; Caldeira & Metelo, Portugal; Elea, Argentina



• Supositorios Glicerina Brota
  Escaned, Spain



• Supositorios Glicerina Calber
  Pentafarm, Spain



• Supositorios Glicerina Cinfa
  Cinfa, Spain



• Supositorios Glicerina Glycilax
  Rovi, Spain



• Supositorios Glicerina Mandri
  Mandri, Spain



• Supositorios Glicerina Rovi
  Pfizer, Spain



• Supositorios Glicerina Torrent
  Torrents, Spain



• Supositorios Glicerina Vilardell
  Vilardell, Spain



• Supositorios Glicerina Viviar
  Viviar, Spain



• Supositorios Glicerina
  Valma, Chile



• Supositorios Senosiain
  Senosiain, Dominican Republic; Senosiain, Guatemala; Senosiain, Honduras; Senosiain, Mexico; Senosiain, Panama; Senosiain, El Salvador



• Supozitoare cu Glicerinã
  Antibiotice, Romania



• Suppositoria cum glycerolo et gelatina
  Qualiphar, Belgium



• Suppositoria Glycerini Galvex
  Galvex, Slovakia



• Suppositoria Glycerini Leciva
  Zentiva, Czech Republic; Zentiva, Slovakia



• Supposte Glicerina Carlo Erba
  Carlo Erba, Italy



• Supposte Glicerina S.Pellegrino
  Sanofi-Aventis, Italy



• Thymol Glycerin Compound (Glycerol and Thymol)
  PSM, New Zealand



• Verolax
  Angelini, Italy; Angelini, Portugal; Farma Lepori, Spain



• Vifticol
  F.T. Pharma, Vietnam



• Vitrosups
  Llorens, Spain



• Vixorfit
  Gezzi, Argentina



• Xin Long Glycerol Enema
  Winguide Huangpu, China



• Zetalax
  Zeta, Italy

International Drug Name Search

Glossary

DCF	Dénomination Commune Française
IS	Inofficial Synonym
JAN	Japanese Accepted Name
OS	Official Synonym
PH	Pharmacopoeia Name
Rec.INN	Recommended International Nonproprietary Name (World Health Organization)

Click for further information on drug naming conventions and International Nonproprietary Names.

Edetate Disodium

Edetate Disodium may be available in the countries listed below.

Ingredient matches for Edetate Disodium

Edetic Acid

Edetic Acid disodium salt (a derivative of Edetic Acid) is reported as an ingredient of Edetate Disodium in the following countries:

• New Zealand

International Drug Name Search

Folinato Calcico Genfarma

Folinato Calcico Genfarma may be available in the countries listed below.

Ingredient matches for Folinato Calcico Genfarma

Calcium Folinate

Calcium Folinate is reported as an ingredient of Folinato Calcico Genfarma in the following countries:

• Spain

International Drug Name Search

Flunarin

Flunarin may be available in the countries listed below.

Ingredient matches for Flunarin

Flunarizine

Flunarizine is reported as an ingredient of Flunarin in the following countries:

• Dominican Republic


• Sri Lanka

Flunarizine dihydrochloride (a derivative of Flunarizine) is reported as an ingredient of Flunarin in the following countries:

• Brazil

International Drug Name Search

diflunisal

dye-FLOO-ni-sal

Oral route(Tablet)

NSAIDs may cause an increased risk of serious cardiovascular thrombotic events, myocardial infarction, and stroke, which can be fatal. This risk may be increased in patients with cardiovascular disease or risk factors for cardiovascular disease. Diflunisal is contraindicated for the treatment of perioperative pain in the setting of CABG surgery. NSAIDs can also cause an increased risk of serious gastrointestinal adverse events especially in the elderly, including bleeding, ulceration, and perforation of the stomach or intestines, which can be fatal .

Commonly used brand name(s)

In the U.S.

• Dolobid

Available Dosage Forms:

• Tablet

Therapeutic Class: Analgesic

Pharmacologic Class: NSAID

Chemical Class: Salicylate, Non-Aspirin

Uses For diflunisal

Diflunisalis a nonsteroidal anti-inflammatory drug (NSAID) used to treat mild to moderate pain, and helps to relieve symptoms of arthritis (osteoarthritis and rheumatoid arthritis), such as inflammation, swelling, stiffness, and joint pain. diflunisal does not cure arthritis and will help you only as long as you continue to take it .

diflunisal is available only with your doctor's prescription .

Before Using diflunisal

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For diflunisal, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to diflunisal or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies have not been performed on the relationship of age to the effects of diflunisal in children below 12 years of age. Safety and efficacy have not been established .

Geriatric

Appropriate studies performed to date have not demonstrated geriatrics-specific problems that would limit the usefulness of diflunisal in the elderly. However, elderly patients are more likely to have age-related kidney problems, which may require adjustment of dosage in patients receiving diflunisal .

Pregnancy

	Pregnancy Category	Explanation
All Trimesters	C	Animal studies have shown an adverse effect and there are no adequate studies in pregnant women OR no animal studies have been conducted and there are no adequate studies in pregnant women.

Breast Feeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Interactions with Medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking diflunisal, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using diflunisal with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

• Ketorolac


• Pentoxifylline

Using diflunisal with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

• Abciximab


• Ardeparin


• Argatroban


• Beta Glucan


• Bivalirudin


• Certoparin


• Cilostazol


• Citalopram


• Clopidogrel


• Clovoxamine


• Dabigatran Etexilate


• Dalteparin


• Danaparoid


• Dipyridamole


• Enoxaparin


• Escitalopram


• Femoxetine


• Flesinoxan


• Fluoxetine


• Fluvoxamine


• Fondaparinux


• Ginkgo


• Heparin


• Lepirudin


• Methotrexate


• Nadroparin


• Nefazodone


• Parnaparin


• Paroxetine


• Pemetrexed


• Phenprocoumon


• Protein C


• Reviparin


• Rivaroxaban


• Sertraline


• Sibutramine


• Tacrolimus


• Ticlopidine


• Tinzaparin


• Tirofiban


• Vilazodone


• Zimeldine

Using diflunisal with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

• Acebutolol


• Acenocoumarol


• Acetohexamide


• Alacepril


• Alprenolol


• Amiloride


• Anisindione


• Arotinolol


• Atenolol


• Azilsartan Medoxomil


• Azosemide


• Befunolol


• Bemetizide


• Benazepril


• Bendroflumethiazide


• Benzthiazide


• Betaxolol


• Bevantolol


• Bisoprolol


• Bopindolol


• Bucindolol


• Bumetanide


• Bupranolol


• Buthiazide


• Candesartan Cilexetil


• Canrenoate


• Captopril


• Carteolol


• Carvedilol


• Celiprolol


• Chlorothiazide


• Chlorpropamide


• Chlorthalidone


• Cilazapril


• Clopamide


• Cyclopenthiazide


• Cyclosporine


• Delapril


• Desvenlafaxine


• Dicumarol


• Dilevalol


• Duloxetine


• Enalaprilat


• Enalapril Maleate


• Eprosartan


• Esmolol


• Ethacrynic Acid


• Fosinopril


• Furosemide


• Gliclazide


• Glimepiride


• Glipizide


• Gliquidone


• Glyburide


• Hydrochlorothiazide


• Hydroflumethiazide


• Imidapril


• Indapamide


• Irbesartan


• Labetalol


• Landiolol


• Levobetaxolol


• Levobunolol


• Lisinopril


• Losartan


• Mepindolol


• Methyclothiazide


• Metipranolol


• Metolazone


• Metoprolol


• Milnacipran


• Moexipril


• Nadolol


• Nebivolol


• Nipradilol


• Olmesartan Medoxomil


• Oxprenolol


• Penbutolol


• Pentopril


• Perindopril


• Pindolol


• Piretanide


• Polythiazide


• Propranolol


• Quinapril


• Ramipril


• Sotalol


• Spirapril


• Spironolactone


• Talinolol


• Tasosartan


• Telmisartan


• Temocapril


• Tertatolol


• Timolol


• Tolazamide


• Tolbutamide


• Torsemide


• Trandolapril


• Triamterene


• Trichlormethiazide


• Valsartan


• Venlafaxine


• Warfarin


• Xipamide


• Zofenopril

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Other Medical Problems

The presence of other medical problems may affect the use of diflunisal. Make sure you tell your doctor if you have any other medical problems, especially:

• Anemia or


• Asthma or


• Bleeding problems or


• Blood clots or


• Edema (fluid retention or body swelling) or


• Heart attack, history of


• Heart disease (e.g., congestive heart failure) or


• High blood pressure or


• Kidney disease or


• Liver disease (e.g., hepatitis) or


• Stomach or intestinal ulcers or bleeding or


• Stroke, history of—Use with caution. diflunisal may make these conditions worse .

• Aspirin sensitivity, history of—diflunisal should NOT be used in patients with this condition .

• Heart surgery (e.g., coronary artery bypass graft [CABG] surgery)—diflunisal should NOT be used to relieve pain right before or after the surgery .

Proper Use of diflunisal

For safe and effective use of diflunisal, do not take more of it, do not take it more often, and do not take it for a longer time than ordered by your doctor. Taking too much of diflunisal may increase the chance of unwanted effects, especially in elderly patients .

When used for severe or continuing arthritis, diflunisal must be taken regularly as ordered by your doctor in order for it to help you. diflunisal usually begins to work within one week, but in severe cases up to two weeks or even longer may pass before you begin to feel better. Also, several weeks may pass before you feel the full effects of diflunisal.

Swallow the tablet whole with a full glass of water. Do not crush or chew it .

To lessen stomach upset, you may take diflunisal with food.

Dosing

The dose of diflunisal will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of diflunisal. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

• For oral dosage form (tablets):
  
  • For mild to moderate pain:
    
    • Adults and teenagers—1000 milligrams (mg) for the first dose, then 500 mg every eight to twelve hours as needed. Some people may need only 500 mg for the first dose, then 250 mg every eight to twelve hours as needed. Usually, no more than a total of 1500 mg a day should be taken.
    
    
    • Children below 12 years of age—Use and dose must be determined by your doctor .
    
    
  
  
  • For osteoarthritis and rheumatoid arthritis:
    
    • Adults and teenagers—At first, 250 or 500 mg twice a day. Your doctor may increase or decrease your dose as needed. However, the dose usually is not more than 1500 mg once a day.
    
    
    • Children below 12 years of age—Use and dose must be determined by your doctor .
    
    
  
  

Missed Dose

If you miss a dose of diflunisal, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Precautions While Using diflunisal

It is very important that your doctor check your progress at regular visits. This will allow your doctor to see if the medicine is working properly and to decide if you should continue to take it. Blood and urine tests may be needed to check for unwanted effects .

diflunisal may raise your risk of having a heart attack or stroke. This is more likely in people who already have heart disease. People who use diflunisal for a long time might also have a higher risk .

diflunisal may cause bleeding in your stomach or intestines. These problems can happen without warning signs. This is more likely if you have had a stomach ulcer in the past, if you smoke or drink alcohol regularly, if you are over 60 years old, if you are in poor health, or if you are using certain other medicines (a steroid or a blood thinner) .

diflunisal can cause a rare but serious illness called Reye's syndrome. It occurs mostly in children and teenagers, but can affect someone at any age. Do not give diflunisal to anyone who has chicken pox or symptoms of a virus or the flu, unless your doctor has told you to. If a child has behavior changes along with nausea and vomiting while using diflunisal, .

Serious skin reactions can occur during treatment with diflunisal. Check with your doctor right away if you have any of the following symptoms while taking diflunisal: blistering, peeling, loosening of skin, chills, cough, diarrhea, fever, itching, joint or muscle pain, red skin lesions, sore throat, sores ulcers, white spots in mouth or on lips, or unusual tiredness or weakness .

Possible warning signs of some serious side effects that can occur during treatment with diflunisal may include swelling of the face, fingers, feet, and/or lower legs; severe stomach pain, black, tarry stools, and/or vomiting of blood or material that looks like coffee grounds; unusual weight gain; yellow skin or eyes; decreased urination; bleeding or bruising; and/or skin rash. Also, signs of serious heart problems could occur such as chest pain, tightness in chest, fast or irregular heartbeat, unusual flushing or warmth of skin, weakness, or slurring of speech. Stop taking diflunisal and check with your doctor immediately if you notice any of these warning signs .

diflunisal may also cause a serious type of allergic reaction called anaphylaxis. Although this is rare, it may occur more often in patients who are allergic to aspirin or to any of the nonsteroidal anti-inflammatory drugs. Anaphylaxis requires immediate medical attention. The most serious signs of this reaction are very fast or irregular breathing, gasping for breath, wheezing, or fainting. Other signs may include changes in color of the skin of the face; very fast but irregular heartbeat or pulse; hive-like swellings on the skin; and puffiness or swellings of the eyelids or around the eyes. If these effects occur, get emergency help at once .

Using diflunisal while you are pregnant can harm your unborn baby. If you think you have become pregnant while using diflunisal, tell your doctor right away .

Check with your doctor immediately if blurred vision, difficulty in reading, or any other change in vision occurs during or after your treatment. Your doctor may want you to have your eyes checked by an ophthalmologist (eye doctor) .

Before having any kind of surgery or medical tests, tell your doctor that you are taking diflunisal. It may be necessary for you to stop treatment for a while, or to change to a different nonsteroidal anti-inflammatory drug before your procedure .

diflunisal Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

More common

• Stomach cramps or pain

Less common

• Back or leg pains


• bleeding gums


• blistering, peeling, loosening of skin


• bloody or black, tarry stools


• bloody or cloudy urine


• blurred or loss of vision


• burning feeling in chest or stomach


• burning while urinating


• clay-colored stools


• constipation


• cough or hoarseness


• cracks in the skin


• dark-colored urine


• diarrhea


• difficult or painful urination


• difficulty breathing


• difficulty swallowing


• disturbed color perception


• dizziness


• double vision


• facial swelling


• fast heartbeat


• feeling of warmth


• fever with or without chills


• flu-like symptoms


• general body swelling


• general feeling of tiredness or weakness


• greatly decreased frequency of urination or amount of urine


• halos around lights


• headache


• hives


• increased blood pressure


• increased thirst


• indigestion


• itching


• joint or muscle pain


• large, hive-like swelling on face, eyelids, lips, tongue, throat, hands, legs, feet, sex organs


• light-colored stools


• liver function abnormalities


• loss of appetite


• loss of heat from the body


• lower back or side pain


• muscle aches, pains, or weakness


• nausea or vomiting


• night blindness


• noisy breathing


• nosebleeds


• overbright appearance of lights


• pale skin


• pinpoint red spots on skin


• puffiness or swelling of the eyelids or around the eyes, face, lips or tongue


• red, irritated eyes


• redness of the face, neck, arms and occasionally, upper chest


• red skin lesions, often with a purple center


• red, swollen skin


• scaly skin


• severe or continuing stomach pain


• shortness of breath


• skin rash


• sores, ulcers, or white spots in mouth or on lips


• sore throat


• stomach upset


• swelling of face, fingers, feet or lower legs


• swollen lymph nodes


• tenderness in stomach area


• tightness in chest


• troubled breathing


• tunnel vision


• unpleasant breath odor


• unusual bleeding or bruising


• unusual tiredness or weakness


• upper right abdominal pain


• vomiting of blood or material that looks like coffee grounds


• weight gain


• wheezing


• yellow eyes or skin

Symptoms of overdose

• Change in consciousness


• confusion about identity, place, and time


• continuing ringing or buzzing or other unexplained noise in ears


• decreased awareness or responsiveness


• deep or fast breathing with dizziness


• fast, pounding, or irregular heartbeat or pulse


• hearing loss


• loss of consciousness


• numbness of feet, hands, and around mouth


• severe sleepiness


• sweating

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

• Acid or sour stomach


• belching


• heartburn


• indigestion


• stomach discomfort or upset

Less common

• Bloated, full feeling


• burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings


• discouragement


• dry mucous membranes


• excess air or gas in stomach or intestines


• feeling of constant movement of self or surroundings


• feeling sad or empty


• increased sensitivity of skin to sunlight


• irritability


• lack or loss of strength


• lightheadedness


• loss of interest or pleasure


• mood or mental changes


• nervousness


• passing gas


• seeing, hearing, or feeling things that are not there


• sensation of spinning


• severe sunburn


• sleeplessness


• swelling or inflammation of the mouth


• tiredness


• trouble concentrating


• trouble sleeping


• unable to sleep


• weight loss

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

See also: diflunisal side effects (in more detail)

The information contained in the Thomson Reuters Micromedex products as delivered by Drugs.com is intended as an educational aid only. It is not intended as medical advice for individual conditions or treatment. It is not a substitute for a medical exam, nor does it replace the need for services provided by medical professionals. Talk to your doctor, nurse or pharmacist before taking any prescription or over the counter drugs (including any herbal medicines or supplements) or following any treatment or regimen. Only your doctor, nurse, or pharmacist can provide you with advice on what is safe and effective for you.

The use of the Thomson Reuters Healthcare products is at your sole risk. These products are provided "AS IS" and "as available" for use, without warranties of any kind, either express or implied. Thomson Reuters Healthcare and Drugs.com make no representation or warranty as to the accuracy, reliability, timeliness, usefulness or completeness of any of the information contained in the products. Additionally, THOMSON REUTERS HEALTHCARE MAKES NO REPRESENTATION OR WARRANTIES AS TO THE OPINIONS OR OTHER SERVICE OR DATA YOU MAY ACCESS, DOWNLOAD OR USE AS A RESULT OF USE OF THE THOMSON REUTERS HEALTHCARE PRODUCTS. ALL IMPLIED WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE OR USE ARE HEREBY EXCLUDED. Thomson Reuters Healthcare does not assume any responsibility or risk for your use of the Thomson Reuters Healthcare products.

More diflunisal resources

• Diflunisal Side Effects (in more detail)
• Diflunisal Dosage
• Diflunisal Use in Pregnancy & Breastfeeding
• Drug Images
• Diflunisal Drug Interactions
• Diflunisal Support Group
• 5 Reviews for Diflunisal - Add your own review/rating

• diflunisal Concise Consumer Information (Cerner Multum)


• Diflunisal Prescribing Information (FDA)


• Diflunisal Professional Patient Advice (Wolters Kluwer)


• Diflunisal MedFacts Consumer Leaflet (Wolters Kluwer)


• Diflunisal Monograph (AHFS DI)

Compare diflunisal with other medications

• Osteoarthritis
• Pain
• Rheumatoid Arthritis

Salobel

Salobel may be available in the countries listed below.

Ingredient matches for Salobel

Allopurinol

Allopurinol is reported as an ingredient of Salobel in the following countries:

• Japan

International Drug Name Search

Tobi

Tobi is a brand name of tobramycin, approved by the FDA in the following formulation(s):

TOBI (tobramycin - solution; inhalation)

• 
  Manufacturer: NOVARTIS PHARMS
  
  Approval date: December 22, 1997
  
  Strength(s): 300MG/5ML ^[RLD]

Has a generic version of Tobi been approved?

No. There is currently no therapeutically equivalent version of Tobi available.

Note: Fraudulent online pharmacies may attempt to sell an illegal generic version of Tobi. These medications may be counterfeit and potentially unsafe. If you purchase medications online, be sure you are buying from a reputable and valid online pharmacy. Ask your health care provider for advice if you are unsure about the online purchase of any medication.

See also: About generic drugs.

Related Patents

Patents are granted by the U.S. Patent and Trademark Office at any time during a drug's development and may include a wide range of claims.

• 
  Aminoglycoside formulation for aerosolization
  Patent 5,508,269
  Issued: April 16, 1996
  Inventor(s): Smith; Arnold L. & Ramsey; Bonnie W. & Montgomery; Alan B.
  Assignee(s): Pathogenesis Corporation
  An aminoglycoside formulation for delivery by aerosolization. The concentrated aminoglycoside formulation containing an efficacious amount of aminoglycoside able to inhibit 95-100% of susceptible bacteria. Aminoglycoside formulated in 5 ml solution of a quarter normal saline having pH between 5.5 and 6.5. The method for treatment of endobronchial infections by a produced by a formulation delivered as an aerosol having mass medium average diameter predominantly between 1 to 5 .mu., produced by a jet or ultrasonic nebulizer.
  
  Patent expiration dates:
  
  
  • October 19, 2014
    
    ✓ 
    Patent use: TREATMENT OF CYSTIC FIBROSIS PATIENTS WITH PSEUDOMONAS AERUGINOSA
    ✓ 
    Drug product
  
  

See also...

• Tobi Solution Consumer Information (Wolters Kluwer)
• Tobi inhalation Consumer Information (Cerner Multum)
• Tobi Advanced Consumer Information (Micromedex)
• Tobi AHFS DI Monographs (ASHP)
• Tobramycin Consumer Information (Wolters Kluwer)
• Tobramycin Solution Consumer Information (Wolters Kluwer)
• Tobramycin inhalation Consumer Information (Cerner Multum)
• Tobramycin injection Consumer Information (Cerner Multum)
• Tobramycin Inhalation Advanced Consumer Information (Micromedex)
• Tobramycin Injection Advanced Consumer Information (Micromedex)
• Tobramycin Sulfate AHFS DI Monographs (ASHP)

Felodipin Hexal

Felodipin Hexal may be available in the countries listed below.

Ingredient matches for Felodipin Hexal

Felodipine

Felodipine is reported as an ingredient of Felodipin Hexal in the following countries:

• Austria


• Denmark


• Estonia


• Hungary


• Latvia


• Lithuania


• Norway


• Sweden

International Drug Name Search

Neomerck

Neomerck may be available in the countries listed below.

Ingredient matches for Neomerck

Ciclosporin

Ciclosporin is reported as an ingredient of Neomerck in the following countries:

• Japan

International Drug Name Search

Lopena

Lopena may be available in the countries listed below.

Ingredient matches for Lopena

Loperamide

Loperamide hydrochloride (a derivative of Loperamide) is reported as an ingredient of Lopena in the following countries:

• Japan

International Drug Name Search

Dexambutol

Dexambutol may be available in the countries listed below.

Ingredient matches for Dexambutol

Ethambutol

Ethambutol dihydrochloride (a derivative of Ethambutol) is reported as an ingredient of Dexambutol in the following countries:

• France


• Greece

International Drug Name Search

Nörotrop

Nörotrop may be available in the countries listed below.

Ingredient matches for Nörotrop

Piracetam

Piracetam is reported as an ingredient of Nörotrop in the following countries:

• Turkey

International Drug Name Search

Rhinos Junior

Rhinos Junior may be available in the countries listed below.

Ingredient matches for Rhinos Junior

Chlorphenamine

Chlorphenamine maleate (a derivative of Chlorphenamine) is reported as an ingredient of Rhinos Junior in the following countries:

• Indonesia

Pseudoephedrine

Pseudoephedrine hydrochloride (a derivative of Pseudoephedrine) is reported as an ingredient of Rhinos Junior in the following countries:

• Indonesia

International Drug Name Search

Gonif

Gonif may be available in the countries listed below.

Ingredient matches for Gonif

Cefuroxime

Cefuroxime sodium salt (a derivative of Cefuroxime) is reported as an ingredient of Gonif in the following countries:

• Greece

International Drug Name Search

Prazepam

Scheme

Rec.INN

ATC (Anatomical Therapeutic Chemical Classification)

N05BA11

CAS registry number (Chemical Abstracts Service)

0002955-38-6

Chemical Formula

C19-H17-Cl-N2-O

Molecular Weight

324

Therapeutic Categories

Anxiolytic agent

Benzodiazepine derivative

Chemical Name

2H-1,4-Benzodiazepin-2-one, 7-chloro-1-(cyclopropylmethyl)-1,3-dihydro-5-phenyl-

Foreign Names

• Prazepamum (Latin)
• Prazepam (German)
• Prazépam (French)
• Prazepam (Spanish)

Generic Names

• Prazepam (OS: BAN, DCIT, USAN, JAN)
• Prazépam (OS: DCF)
• K 373 (IS)
• W 4020 (IS)
• Prazepam (PH: BP 2010, JP XIV, USP 23, Ph. Eur. 6)
• Prazépam (PH: Ph. Eur. 6)
• Prazepamum (PH: Ph. Eur. 6)

Brand Names

• Centrac
  Pfizer, Greece



• Centrax
  Parke Davis, Ireland



• Demetrin
  Hemofarm, Serbia; Pfizer, Austria; Pfizer, Switzerland; Pfizer, Germany; Pfizer, Portugal; Pfizer, South Africa



• Lysanxia
  Pfizer, Belgium; Pfizer, Burkina Faso; Pfizer, Benin; Pfizer, Central African Republic; Pfizer, Congo; Pfizer, Cote D'ivoire; Pfizer, Cameroon; Pfizer, Gabon; Pfizer, Guinea; Pfizer, Luxembourg; Pfizer, Madagascar; Pfizer, Mali; Pfizer, Mauritania; Pfizer, Mauritius; Pfizer, Niger; Pfizer, Senegal; Pfizer, Chad; Pfizer, Togo; Pfizer, Tunisia; Pfizer, Zaire; Sigma Tau, France



• Mono Demetrin
  Gödecke, Germany; Pfizer, Germany



• Prasepine
  Pfizer, Thailand



• Prazene
  Pfizer, Italy



• Reapam
  Pfizer, Netherlands



• Sedapran
  Kowa Souyaku, Japan



• Trepidan
  Max Farma, Italy

International Drug Name Search

Glossary

BAN	British Approved Name
DCF	Dénomination Commune Française
DCIT	Denominazione Comune Italiana
IS	Inofficial Synonym
JAN	Japanese Accepted Name
OS	Official Synonym
PH	Pharmacopoeia Name
Rec.INN	Recommended International Nonproprietary Name (World Health Organization)
USAN	United States Adopted Name

Click for further information on drug naming conventions and International Nonproprietary Names.

Bromtuss DM

Generic Name: brompheniramine, dextromethorphan, and phenylephrine (brome fen IR a meen, dex troe metho OR fan, fen il EFF rin)

Brand Names: Alacol DM, Alahist DM, BP Allergy DM, BPM PE DM, Bromatan-DM, Bromtuss DM, BroveX PEB DM, Children's Cold & Cough DM, Cold & Cough Childrens, Dimaphen DM, Dimetapp Cold & Cough, Dimetapp DM Cold & Cough, DuraTan DM, Duravent DPB, Lohist-DM, Lortuss DM (obsolete), Tusdec-DM

What is Bromtuss DM (brompheniramine, dextromethorphan, and phenylephrine)?

Brompheniramine is an antihistamine that reduces the natural chemical histamine in the body. Histamine can produce symptoms of sneezing, itching, watery eyes, and runny nose.

Dextromethorphan is a cough suppressant. It affects the signals in the brain that trigger cough reflex.

Phenylephrine is a decongestant that shrinks blood vessels in the nasal passages. Dilated blood vessels can cause nasal congestion (stuffy nose).

Brompheniramine, dextromethorphan, and phenylephrine is used to treat sneezing, cough, runny or stuffy nose, itchy or watery eyes, hives, skin rash, itching, and other symptoms of allergies and the common cold.

Dextromethorphan will not treat a cough that is caused by smoking, asthma, or emphysema.

Brompheniramine, dextromethorphan, and phenylephrine may also be used for other purposes not listed in this medication guide.

What is the most important information I should know about Bromtuss DM (brompheniramine, dextromethorphan, and phenylephrine)?

Always ask a doctor before giving a cough or cold medicine to a child. Death can occur from the misuse of cough and cold medicines in very young children. Do not use any other over-the-counter cough, cold, or sleep medication without first asking your doctor or pharmacist. If you take certain products together you may accidentally take too much of a certain drug. Read the label of any other medicine you are using to see if it contains an antihistamine, decongestant, or cough suppressant. Do not use a cough or cold medicine if you have used an MAO inhibitor such as isocarboxazid (Marplan), phenelzine (Nardil), rasagiline (Azilect), selegiline (Eldepryl, Emsam), or tranylcypromine (Parnate) within the past 14 days. Serious, life-threatening side effects can occur if you take cough or cold medicine before the MAO inhibitor has cleared from your body. Brompheniramine, dextromethorphan, and phenylephrine can cause side effects that may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be awake and alert. Avoid drinking alcohol. It can increase some of the side effects of this medication.

What should I discuss with my healthcare provider before taking Bromtuss DM (brompheniramine, dextromethorphan, and phenylephrine)?

Do not use a cough or cold medicine if you have used an MAO inhibitor such as isocarboxazid (Marplan), phenelzine (Nardil), rasagiline (Azilect), selegiline (Eldepryl, Emsam), or tranylcypromine (Parnate) within the past 14 days. Serious, life-threatening side effects can occur if you take cough or cold medicine before the MAO inhibitor has cleared from your body.

Before taking this medication, tell your doctor if you are allergic to brompheniramine, dextromethorphan, or phenylephrine, or if you have:

• kidney disease;


• liver disease;


• 
  

  diabetes;

  
  


• 
  

  glaucoma;

  
  


• 
  

  heart disease or high blood pressure;

  
  


• 
  

  diabetes;

  
  


• 
  

  a thyroid disorder;

  
  


• 
  

  a stomach ulcer or a stomach obstruction,

  
  


• 
  

  emphysema or chronic bronchitis; or

  
  


• 
  

  an enlarged prostate or urination problems.

  
  

If you have any of these conditions, you may need a dose adjustment or special tests to safely take this medication.

FDA pregnancy category C. This medication may be harmful to an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment. Brompheniramine, dextromethorphan, and phenylephrine can pass into breast milk and may harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.

Artificially-sweetened liquid forms of cough-and-cold medications may contain phenylalanine. This would be important to know if you have phenylketonuria (PKU). Check the ingredients and warnings on the medication label if you are concerned about phenylalanine.

How should I take Bromtuss DM (brompheniramine, dextromethorphan, and phenylephrine)?

Use this medication exactly as directed on the label or as it was prescribed for you. Do not take the medication in larger amounts, or take it for longer than recommended by your doctor.

Always ask a doctor before giving a cough or cold medicine to a child. Death can occur from the misuse of cough and cold medicines in very young children. Take this medicine with a full glass of water.

Measure the liquid form of this medicine with a special dose-measuring spoon or cup, not a regular table spoon. If you do not have a dose-measuring device, ask your pharmacist where you can get one.

Take this medicine with food or milk if it upsets your stomach.

This medication can cause you to have unusual results with allergy skin tests. Tell any doctor who treats you that you are taking an antihistamine.

Talk with your doctor if your symptoms do not improve after 7 days of treatment, or if you have a fever with a headache, cough, or skin rash.

If you need to have any type of surgery, tell the surgeon ahead of time if you have taken a cold medicine within the past few days.

Store the medication at room temperature away from moisture and heat.

What happens if I miss a dose?

Since cough or cold medicine is usually taken only as needed, you may not be on a dosing schedule. If you are taking the medication regularly, take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and take the medicine at your next regularly scheduled time. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention if you think you have used too much of this medicine.

Overdose symptoms may include feeling restless or nervous, nausea, vomiting, stomach pain, dizziness, drowsiness, dry mouth, warmth or tingly feeling, or seizure (convulsions).

What should I avoid while taking Bromtuss DM (brompheniramine, dextromethorphan, and phenylephrine)?

This medication can cause side effects that may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be awake and alert. Avoid drinking alcohol. It can increase some of the side effects of this medication.

Avoid using other medicines that make you sleepy (such as sleeping pills, pain medication, muscle relaxers, and medicine for seizures, depression or anxiety). They can add to sleepiness caused by brompheniramine, dextromethorphan, and phenylephrine.

Avoid taking diet pills, caffeine pills, or other stimulants (such as ADHD medications) without your doctor's advice. Taking a stimulant together with a decongestant can increase your risk of unpleasant side effects.

Do not use any other over-the-counter cough, cold, or sleep medication without first asking your doctor or pharmacist. If you take certain products together you may accidentally take too much of a certain drug. Read the label of any other medicine you are using to see if it contains an antihistamine, decongestant, or cough suppressant.

Bromtuss DM (brompheniramine, dextromethorphan, and phenylephrine) side effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Stop using this medication and call your doctor at once if you have any of these serious side effects:

• 
  

  fast, pounding, or uneven heartbeat;

  
  


• 
  

  confusion, hallucinations, unusual thoughts or behavior;

  
  


• 
  

  severe dizziness, anxiety, restless feeling, or nervousness;

  
  


• 
  

  increased blood pressure (severe headache, blurred vision, trouble concentrating, chest pain, numbness, seizure);

  
  


• 
  

  confusion, hallucinations, unusual thoughts or behavior;

  
  


• 
  

  slow, shallow breathing;

  
  


• 
  

  urinating less than usual or not at all;

  
  


• 
  

  easy bruising or bleeding, unusual weakness, fever, chills, body aches, flu symptoms; or

  
  


• 
  

  nausea, stomach pain, low fever, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes).

  
  

Less serious side effects may include:

• 
  

  blurred vision;

  
  


• 
  

  dry mouth;

  
  


• 
  

  nausea, stomach pain, constipation;

  
  


• 
  

  mild loss of appetite, stomach upset;

  
  


• 
  

  warmth, tingling, or redness under your skin;

  
  


• 
  

  sleep problems (insomnia);

  
  


• 
  

  restless or excitability (especially in children);

  
  


• 
  

  skin rash or itching;

  
  


• 
  

  dizziness, drowsiness;

  
  


• 
  

  problems with memory or concentration; or

  
  


• 
  

  ringing in your ears.

  
  

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect Bromtuss DM (brompheniramine, dextromethorphan, and phenylephrine)?

Before taking this medication, tell your doctor if you are using any of the following drugs:

• 
  

  an antidepressant;

  
  


• 
  

  a diuretic (water pill);

  
  


• 
  

  medication to treat irritable bowel syndrome;

  
  


• 
  

  celecoxib (Celebrex);

  
  


• 
  

  cinacalcet (Sensipar);

  
  


• 
  

  darifenacin (Enablex);

  
  


• 
  

  imatinib (Gleevec);

  
  


• 
  

  quinidine (Quinaglute, Quinidex);

  
  


• 
  

  ranolazine (Ranexa)

  
  


• 
  

  ritonavir (Norvir);

  
  


• 
  

  sibutramine (Meridia);

  
  


• 
  

  terbinafine (Lamisil);

  
  


• 
  

  medicines to treat high blood pressure;

  
  


• 
  

  aspirin or salicylates (such as Disalcid, Doan's Pills, Dolobid, Salflex, Tricosal, and others);

  
  


• 
  

  bladder or urinary medications such as oxybutynin (Ditropan, Oxytrol) or tolterodine (Detrol); or

  
  


• 
  

  a beta-blocker such as atenolol (Tenormin), carteolol (Cartrol), metoprolol (Lopressor, Toprol), nadolol (Corgard), propranolol (Inderal), sotalol (Betapace), timolol (Blocadren), and others.

  
  

This list is not complete and there may be other drugs that can interact with brompheniramine, dextromethorphan, and phenylephrine. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.

More Bromtuss DM resources

• Bromtuss DM Side Effects (in more detail)
• Bromtuss DM Use in Pregnancy & Breastfeeding
• Bromtuss DM Drug Interactions
• Bromtuss DM Support Group
• 0 Reviews for Bromtuss DM - Add your own review/rating

• Alacol DM Elixir MedFacts Consumer Leaflet (Wolters Kluwer)


• Bromatan-DM Suspension MedFacts Consumer Leaflet (Wolters Kluwer)

Compare Bromtuss DM with other medications

• Cough and Nasal Congestion

Where can I get more information?

• Your pharmacist can provide more information about brompheniramine, dextromethorphan, and phenylephrine.

See also: Bromtuss DM side effects (in more detail)

Quinupristin Mesilate

Quinupristin Mesilate may be available in the countries listed below.

Ingredient matches for Quinupristin Mesilate

Quinupristin

Quinupristin Mesilate (BANM) is known as Quinupristin in the US.

International Drug Name Search

Glossary

BANM	British Approved Name (Modified)

Click for further information on drug naming conventions and International Nonproprietary Names.

Pexol

Pexol may be available in the countries listed below.

Ingredient matches for Pexol

Pentoxifylline

Pentoxifylline is reported as an ingredient of Pexol in the following countries:

• Peru

International Drug Name Search

Poloxalene

In some countries, this medicine may only be approved for veterinary use.

Scheme

Rec.INN

CAS registry number (Chemical Abstracts Service)

0009003-11-6

Therapeutic Category

Laxative

Chemical Name

Oxirane, methyl-, polymer with oxirane, block

Foreign Names

• Poloxalenum (Latin)
• Poloxalen (German)
• Poloxalène (French)
• Poloxaleno (Spanish)

Generic Names

• Poloxalene (OS: USAN, BAN)
• SKF 18 667 (IS)
• Poloxalene (PH: USP 32)

Brand Names

• Bloat Guard (veterinary use)
  Agrimin, United Kingdom; Pfizer Animal Health, United States; Phibro Animal Health, United States



• Easylix Bloat Guard (veterinary use)
  Ridley, United States



• Purina (veterinary use)
  Virbac, United States



• Therabloat (veterinary use)
  Pfizer Animal Health, United States

International Drug Name Search

Glossary

BAN	British Approved Name
IS	Inofficial Synonym
OS	Official Synonym
PH	Pharmacopoeia Name
Rec.INN	Recommended International Nonproprietary Name (World Health Organization)
USAN	United States Adopted Name

Click for further information on drug naming conventions and International Nonproprietary Names.

Baycadron

dexamethasone

Dosage Form: elixir
Baycadron™ ELIXIR

(Dexamethasone Elixir, USP

0.5 mg/5 mL)

Baycadron Description

Each 5 mL (teaspoonful) contains:

Dexamethasone, USP……….……….…………………………. 0.5 mg

Also contains:

Benzoic Acid, USP……………………………………………….. 0.1%

  (as preservative)

Alcohol……………………………………………………………. 5.1%

Inactive Ingredients: Artificial Raspberry Flavor; Citric Acid, USP; FD&C Red No. 40; Liquid Sugar; Propylene Glycol, USP and Purified Water, USP. It may also contain Sodium Citrate, USP.

Glucocorticoids are adrenocortical steroids, both naturally occurring and synthetic, which are readily absorbed from the gastrointestinal tract.

Dexamethasone, a synthetic adrenocortical steroid, is a white to practically white, odorless, crystalline powder. It is stable in air. It is practically insoluble in water. The molecular weight is 392.47. It is designated chemically as 9-fluoro-11β,17,21-trihydroxy-16α-methylpregna-1,4-diene-3,20-dione. The molecular formula is C22H29FO5 and the structural formula is:

Baycadron - Clinical Pharmacology

Naturally occurring glucocorticoids, (hydrocortisone and cortisone), which also have salt-retaining properties, are used as replacement therapy in adrenocortical deficiency states. Their synthetic analogs, including dexamethasone, are primarily used for their potent anti-inflammatory effects in disorders of many organ systems.

Glucocorticoids cause profound and varied metabolic effects. In addition, they modify the body's immune responses to diverse stimuli.

At equipotent anti-inflammatory doses, dexamethasone almost completely lacks the sodium-retaining property of hydrocortisone and closely related derivatives of hydrocortisone.

Indications and Usage for Baycadron

1. Endocrine Disorders

Primary or secondary adrenocortical insufficiency (hydrocortisone or cortisone is the first choice; synthetic analogs may be used in conjunction with mineralocorticoids where applicable; in infancy mineralocorticoid supplementation is of particular importance).

 

Congenital adrenal hyperplasia

 

Nonsuppurative thyroiditis

 

Hypercalcemia associated with cancer

2. Rheumatic Disorders

As adjunctive therapy for short-term administration (to tide the patient over an acute episode or exacerbation) in:

 

Psoriatic arthritis

 

Rheumatoid arthritis, including juvenile rheumatoid arthritis (selected cases may require low-dose maintenance therapy)

 

Ankylosing spondylitis

 

Acute and subacute bursitis

 

Acute nonspecific tenosynovitis

 

Acute gouty arthritis

 

Post-traumatic osteoarthritis

 

Synovitis of osteoarthritis

 

Epicondylitis

3. Collagen Diseases

During an exacerbation or as maintenance therapy in selected cases of:

 

Systemic lupus erythematosus

 

Acute rheumatic carditis

4. Dermatologic Diseases

 

Pemphigus

 

Bullous dermatitis herpetiformis

 

Severe erythema multiforme (Stevens-Johnson syndrome)

 

Exfoliative dermatitis

 

Mycosis fungoides

 

Severe psoriasis

 

Severe seborrheic dermatitis

5. Allergic States

Control of severe or incapacitating allergic conditions intractable to adequate trials of conventional treatment:

 

Seasonal or perennial allergic rhinitis

 

Bronchial asthma

 

Contact dermatitis

 

Atopic dermatitis

 

Serum sickness

 

Drug hypersensitivity reactions

6. Ophthalmic Diseases

Severe acute and chronic allergic and inflammatory processes involving the eye and its adnexa, such as:

 

Allergic conjunctivitis

 

Keratitis

 

Allergic corneal marginal ulcers

 

Herpes zoster ophthalmicus

 

Iritis and iridocyclitis

 

Chorioretinitis

 

Anterior segment inflammation

 

Diffuse posterior uveitis and choroiditis

 

Optic neuritis

 

Sympathetic ophthalmia

7. Respiratory Diseases

 

Symptomatic sarcoidosis

 

Loeffler's syndrome not manageable by other means

 

Berylliosis

 

Fulminating or disseminated pulmonary tuberculosis when used concurrently with appropriate antituberculous chemotherapy

 

Aspiration pneumonitis

8. Hematologic Disorders

 

Idiopathic thrombocytopenic purpura in adults

 

Secondary thrombocytopenia in adults

 

Acquired (autoimmune) hemolytic anemia

 

Erythroblastopenia (RBC anemia)

 

Congenital (erythroid) hypoplastic anemia

9. Neoplastic Diseases

For palliative management of:

 

Leukemia and lymphomas in adults

 

Acute leukemia of childhood

10. Edematous States

To induce a diuresis or remission of proteinuria in the nephrotic syndrome, without uremia, of the idiopathic type or that due to lupus erythematosus

11. Gastrointestinal Diseases

To tide the patient over a critical period of the disease in:

 

Ulcerative colitis

 

Regional enteritis

12. Miscellaneous

 

Tuberculous meningitis with subarachnoid block or impending block when used concurrently with appropriate antituberculous chemotherapy

 

Trichinosis with neurologic or myocardial involvement

13. Diagnostic testing of adrenocortical hyperfunction

Contraindications

 

Systemic fungal infections

 

Hypersensitivity to this product

Warnings

In patients on corticosteroid therapy subjected to unusual stress, increased dosage of rapidly acting corticosteroids before, during, and after the stressful situation is indicated.

Drug-induced secondary adrenocortical insufficiency may result from too rapid withdrawal of corticosteroids and may be minimized by gradual reduction of dosage. This type of relative insufficiency may persist for months after discontinuation of therapy; therefore, in any situation of stress occurring during that period, hormone therapy should be reinstituted. If the patient is receiving steroids already, dosage may have to be increased. Since mineralocorticoid secretion may be impaired, salt and/or a mineralocorticoid should be administered concurrently.

Corticosteroids may mask some signs of infection, and new infections may appear during their use. There may be decreased resistance and inability to localize infection when corticosteroids are used. Moreover, corticosteroids may affect the nitroblue-tetrazolium test for bacterial infection and produce false-negative results.

In cerebral malaria, a double-blind trial has shown that the use of corticosteroids is associated with prolongation of coma and a higher incidence of pneumonia and gastrointestinal bleeding.

Corticosteroids may activate latent amebiasis. Therefore, it is recommended that latent or active amebiasis be ruled out before initiating corticosteroid therapy in any patient who has spent time in the tropics or any patient with unexplained diarrhea.

Prolonged use of corticosteroids may produce posterior subcapsular cataracts, glaucoma with possible damage to the optic nerves, and may enhance the establishment of secondary ocular infections due to fungi or viruses.

Usage in Pregnancy

Since adequate human reproduction studies have not been done with corticosteroids, use of these drugs in pregnancy or in women of childbearing potential requires that the anticipated benefits be weighed against the possible hazards to the mother and embryo or fetus. Infants born of mothers who have received substantial doses of corticosteroids during pregnancy should be carefully observed for signs of hypoadrenalism.

Corticosteroids appear in breast milk and could suppress growth, interfere with endogenous corticosteroid production, or cause other unwanted effects. Mothers taking pharmacologic doses of corticosteroids should be advised not to nurse.

Average and large doses of hydrocortisone or cortisone can cause elevation of blood pressure, salt and water retention, and increased excretion of potassium. These effects are less likely to occur with the synthetic derivatives except when used in large doses. Dietary salt restriction and potassium supplementation may be necessary. All corticosteroids increase calcium excretion.

Administration of live virus vaccines, including smallpox, is contraindicated in individuals receiving immunosuppressive doses of corticosteroids. If inactivated viral or bacterial vaccines are administered to individuals receiving immunosuppressive doses of corticosteroids, the expected serum antibody response may not be obtained. However, immunization procedures may be undertaken in patients who are receiving corticosteroids as replacement therapy, e.g., for Addison's disease.

Persons who are on drugs which suppress the immune system are more susceptible to infections than healthy individuals. Chickenpox and measles, for example, can have more serious or even fatal course in non-immune children or adults on corticosteroids. In such children or adults who have not had these diseases, particular care should be taken to avoid exposure. How the dose, route and duration of corticosteroid administration affects the risk of developing a disseminated infection is not known. The contribution of the underlying disease and/or prior corticosteroid treatment to the risk is also not known. If exposed to chickenpox, prophylaxis with varicella zoster immune globulin (VZIG) may be indicated. If exposed to measles, prophylaxis with pooled intramuscular immunoglobulin (IG) may be indicated. (See the respective package inserts for complete VZIG and IG prescribing information.) If chickenpox develops, treatment with antiviral agents may be considered.

The use of Baycadron™ Elixir in active tuberculosis should be restricted to those cases of fulminating or disseminated tuberculosis in which the corticosteroid is used for the management of the disease in conjunction with an appropriate antituberculous regimen.

If corticosteroids are indicated in patients with latent tuberculosis or tuberculin reactivity, close observation is necessary as reactivation of the disease may occur. During prolonged corticosteroid therapy, these patients should receive chemoprophylaxis.

Literature reports suggest an apparent association between use of corticosteroids and left ventricular free wall rupture after a recent myocardial infarction; therefore, therapy with corticosteroids should be used with great caution in these patients.

Precautions

Following prolonged therapy, withdrawal of corticosteroids may result in symptoms of the corticosteroid withdrawal syndrome including fever, myalgia, arthralgia, and malaise. This may occur in patients even without evidence of adrenal insufficiency.

There is an enhanced effect of corticosteroids in patients with hypothyroidism and in those with cirrhosis.

Corticosteroids should be used cautiously in patients with ocular herpes simplex because of possible corneal perforation.

The lowest possible dose of corticosteroid should be used to control the condition under treatment, and when reduction in dosage is possible, the reduction should be gradual.

Psychic derangements may appear when corticosteroids are used, ranging from euphoria, insomnia, mood swings, personality changes, and severe depression, to frank psychotic manifestations. Also, existing emotional instability or psychotic tendencies may be aggravated by corticosteroids.

Aspirin should be used cautiously in conjunction with corticosteroids in hypoprothrombinemia.

Steroids should be used with caution in nonspecific ulcerative colitis, if there is a probability of impending perforation, abscess, or other pyogenic infection, diverticulitis, fresh intestinal anastomoses, active or latent peptic ulcer, renal insufficiency, hypertension, osteoporosis and myasthenia gravis. Fat embolism has been reported as a possible complication of hypercortisonism.

When large doses are given, some authorities advise that corticosteroids be taken with meals and antacids taken between meals to help to prevent peptic ulcer.

Growth and development of infants and children on prolonged corticosteroid therapy should be carefully observed.

Steroids may increase or decrease motility and number of spermatozoa in some patients.

Phenytoin, phenobarbital, ephedrine, and rifampin may enhance the metabolic clearance of corticosteroids, resulting in decreased blood levels and lessened physiologic activity, thus requiring adjustment in corticosteroid dosage. These interactions may interfere with dexamethasone suppression tests which should be interpreted with caution during administration of these drugs.

False-negative results in the dexamethasone suppression test (DST) in patients being treated with indomethacin have been reported. Thus, results of the DST should be interpreted with caution in these patients.

The prothrombin time should be checked frequently in patients who are receiving corticosteroids and coumarin anticoagulants at the same time because of reports that corticosteroids have altered the response to these anticoagulants. Studies have shown that the usual effect produced by adding corticosteroids is inhibition of response to coumarins, although there have been some conflicting reports of potentiation not substantiated by studies.

When corticosteroids are administered concomitantly with potassium-depleting diuretics, patients should be observed closely for development of hypokalemia.

Information for Patients

Persons who are on immunosuppressant doses of corticosteroids should be warned to avoid exposure to chickenpox or measles. Patients should also be advised that if they are exposed, medical advice should be sought without delay.

Adverse Reactions

Fluid and Electrolyte Disturbances:

 

Sodium retention

 

Fluid retention

 

Congestive heart failure in susceptible patients

 

Potassium loss

 

Hypokalemic alkalosis

 

Hypertension

Musculoskeletal:

 

Muscle weakness

 

Steroid myopathy

 

Loss of muscle mass

 

Osteoporosis

 

Vertebral compression fractures

 

Aseptic necrosis of femoral and humeral heads

 

Pathologic fracture of long bones

 

Tendon rupture

Gastrointestinal:

 

Peptic ulcer with possible perforation and hemorrhage

 

Perforation of the small and large bowel, particularly in patients with inflammatory bowel disease

 

Pancreatitis

 

Abdominal distention

 

Ulcerative esophagitis

Dermatologic:

 

Impaired wound healing

 

Thin fragile skin

 

Petechiae and ecchymoses

 

Erythema

 

Increased sweating

 

May suppress reactions to skin tests

 

Other cutaneous reactions, such as allergic dermatitis, urticaria, angioneurotic edema

Neurologic:

 

Convulsions

 

Increased intracranial pressure with papilledema (pseudotumor cerebri) usually after treatment

 

Vertigo

 

Headache

 

Psychic Disturbances

Endocrine:

 

Menstrual irregularities

 

Development of cushingoid state

 

Suppression of growth in children

 

Secondary adrenocortical and pituitary unresponsiveness, particularly in times of stress, as in trauma, surgery, or illness

 

Decreased carbohydrate tolerance

 

Manifestations of latent diabetes mellitus

 

Increased requirements for insulin or oral hypoglycemic agents in diabetes

 

Hirsutism

Ophthalmic:

 

Posterior subcapsular cataracts

 

Increased intraocular pressure

 

Glaucoma

 

Exophthalmos

Metabolic:

 

Negative nitrogen balance due to protein catabolism

Cardiovascular:

 

Myocardial rupture following recent myocardial infarction (See WARNINGS)

Other:

 

Hypersensitivity

 

Thromboembolism

 

Weight gain

 

Increased appetite

 

Nausea

 

Malaise

 

Hiccups

Overdosage

Reports of acute toxicity and/or death following overdosage of glucocorticoids are rare. In the event of overdosage, no specific antidote is available; treatment is supportive and symptomatic.

The oral LD50 of dexamethasone in female mice was 6.5 g/kg.

Baycadron Dosage and Administration

For oral administration

DOSAGE REQUIREMENTS ARE VARIABLE AND MUST BE INDIVIDUALIZED ON THE BASIS OF THE DISEASE AND THE RESPONSE OF THE PATIENT.

The initial dosage varies from 0.75 to 9 mg a day depending on the disease being treated. In less severe diseases doses lower than 0.75 mg may suffice, while in severe diseases doses higher than 9 mg may be required. The initial dosage should be maintained or adjusted until the patient's response is satisfactory. If satisfactory clinical response does not occur after a reasonable period of time, discontinue Baycadron™ Elixir and transfer the patient to other therapy.

After a favorable initial response, the proper maintenance dosage should be determined by decreasing the initial dosage in small amounts to the lowest dosage that maintains an adequate clinical response.

Patients should be observed closely for signs that might require dosage adjustment, including changes in clinical status resulting from remissions or exacerbations of the disease, individual drug responsiveness, and the effect of stress (e.g., surgery, infection, trauma). During stress it may be necessary to increase dosage temporarily.

If the drug is to be stopped after more than a few days of treatment, it usually should be withdrawn gradually.

The following milligram equivalents facilitate changing to Baycadron™ Elixir from other glucocorticoids:

Baycadron™ ELIXIR	METHYLPREDNISOLONE AND TRIAMCINOLONE	PREDNISOLONE AND PREDNISONE	HYDROCORTISONE	CORTISONE
0.75 mg =	4 mg =	5 mg =	20 mg =	25 mg

Dexamethasone suppression tests

1. Tests for Cushing's syndrome.
   
   Give 1 mg of Dexamethasone orally at 11:00 p.m. Blood is drawn for plasma cortisol determination at 8:00 a.m. the following morning.
   
   For greater accuracy, give 0.5 mg of Dexamethasone orally every 6 hours for 48 hours. Twenty-four hour urine collections are made for determination of 17-hydroxycorticosteroid excretion.


2. Test to distinguish Cushing's syndrome due to pituitary ACTH excess from Cushing's syndrome due to other causes.
   
   Give 2 mg of Dexamethasone orally every 6 hours for 48 hours. Twenty-four hour urine collections are made for determination of 17-hydroxycorticosteroid excretion.

How is Baycadron Supplied

Baycadron™ Elixir (Dexamethasone Elixir, USP 0.5 mg/5 mL) is supplied as a clear, red, raspberry-flavored liquid in the following size:

8 fl oz (No Dropper) (237 mL)

RECOMMENDED STORAGE

Store at 20° to 25°C (68° to 77°F). [See USP Controlled RoomTemperature].

KEEP TIGHTLY CLOSED

AVOID FREEZING

Dispense in a tight container as defined in the USP.

Rx Only

Product No.: 8810

Manufactured For:

Wockhardt USA, LLC

Parsippany, NJ 07054

Manufactured By:

Morton Grove Pharmaceuticals, Inc.

Morton Grove, IL 60053

28810

ISS. 12-08

PRINCIPAL DISPLAY PANEL - 30 mL Bottle

WOCKHARDT

NDC 64679-810-30

Baycadron™

ELIXIR

(Dexamethasone Elixir,

USP 0.5 mg/5 mL)

PROFESSIONAL SAMPLE –

NOT FOR RESALE

Rx Only

NET: 1 fl oz (30 mL)

Baycadron  dexamethasone  elixir

Product Information Product Type HUMAN PRESCRIPTION DRUG NDC Product Code (Source) 64679-810 Route of Administration ORAL DEA Schedule

Active Ingredient/Active Moiety Ingredient Name Basis of Strength Strength Dexamethasone (Dexamethasone) Dexamethasone 0.5 mg  in 5 mL

Inactive Ingredients Ingredient Name Strength raw sugar   propylene glycol   benzoic acid   alcohol   Anhydrous Citric Acid   FD&C red no. 40   water   sodium citrate   citric acid monohydrate

Product Characteristics Color RED (Clear) Score      Shape Size Flavor RASPBERRY Imprint Code Contains

Packaging # NDC Package Description Multilevel Packaging 1 64679-810-08 30 mL In 1 BOTTLE None

Marketing Information
Marketing Category	Application Number or Monograph Citation	Marketing Start Date	Marketing End Date
ANDA	ANDA088254	07/27/1983

Labeler - Wockhardt USA, LLC (170508365)

Revised: 07/2009Wockhardt USA, LLC

More Baycadron resources

• Baycadron Side Effects (in more detail)
• Baycadron Dosage
• Baycadron Use in Pregnancy & Breastfeeding
• Baycadron Drug Interactions
• Baycadron Support Group
• 0 Reviews for Baycadron - Add your own review/rating

• Baycadron Concise Consumer Information (Cerner Multum)


• Dexamethasone Professional Patient Advice (Wolters Kluwer)


• Dexamethasone Monograph (AHFS DI)


• Cortastat injection Concise Consumer Information (Cerner Multum)


• Decadron Advanced Consumer (Micromedex) - Includes Dosage Information


• Decadron MedFacts Consumer Leaflet (Wolters Kluwer)


• Dexamethasone Sodium Phosphate eent Monograph (AHFS DI)

Compare Baycadron with other medications

• Addison's Disease
• Adrenal Insufficiency
• Adrenocortical Insufficiency
• Adrenogenital Syndrome
• Ankylosing Spondylitis
• Aspiration Pneumonia
• Asthma
• Asthma, acute
• Atopic Dermatitis
• Bronchopulmonary Dysplasia
• Bursitis
• Cerebral Edema
• Chorioretinitis
• Croup
• Cushing's Syndrome
• Dermatitis Herpetiformis
• Eczema
• Epicondylitis, Tennis Elbow
• Erythroblastopenia
• Evan's Syndrome
• Gouty Arthritis
• Hay Fever
• Hemolytic Anemia
• Hypercalcemia of Malignancy
• Idiopathic Thrombocytopenic Purpura
• Inflammatory Bowel Disease
• Inflammatory Conditions
• Iridocyclitis
• Iritis
• Juvenile Rheumatoid Arthritis
• Keratitis
• Leukemia
• Loeffler's Syndrome
• Lymphoma
• Meningitis, Haemophilus influenzae
• Meningitis, Listeriosis
• Meningitis, Meningococcal
• Meningitis, Pneumococcal
• Mountain Sickness / Altitude Sickness
• Multiple Myeloma
• Multiple Sclerosis
• Mycosis Fungoides
• Nausea/Vomiting, Chemotherapy Induced
• Neurosarcoidosis
• Pemphigus
• Psoriatic Arthritis
• Pulmonary Tuberculosis
• Rheumatoid Arthritis
• Sarcoidosis
• Seborrheic Dermatitis
• Shock
• Synovitis
• Systemic Lupus Erythematosus
• Thrombocytopenia
• Toxic Epidermal Necrolysis
• Tuberculous Meningitis
• Ulcerative Colitis
• Uveitis, Posterior